Special programmes

ACPP: Ansell Cytostatic Permeation Program

Dynamic Permeation Device

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The molecules tested are the following

CytostaticBrand nameCompanyAnalytical methodConcentrationDetection limitQuantification limit
1CarmustineNutrimon BICNUAlmirall-ProdesfarmaHPLC-DAD3 mg/ml59.02 ng/ml196.73 ng/ml
2CisplatinePlatinolBristol-Myers SquibbHPLC-DAD1 mg/ml49.70 ng/ml165.67 ng/ml
3CyclophosphamideEndoxanAstaMedicaLCMS/MS20 mg/ml1.95 ng/ml31.60 ng/ml
4CytarabineCytosarPharmacia & UpJohnLCMS/MS100 mg/ml0.97 ng/ml4.93 ng/ml
5DocetaxelTaxotereAventis PharmaLCMS/MS10 mg/ml3.11 ng/ml17.32 ng/ml
6DoxorubicinAdriblastinaPharmaciaLCMS/MS2 mg/ml35.26 ng/ml55.10 ng/ml
7EtoposideVepesidBristol-Myers SquibbHPLC-DAD20 mg/ml63.06 ng/ml210.19 ng/ml
85-FluorouracilFluoroblastinePharmacia & UpJohnHPLC-DAD50 mg/ml37.47 ng/ml124.92 ng/ml
9IfosfamideHoloxanAstaMedicaLCMS/MS100 mg/ml4.11 ng/ml45.11 ng/ml
10IrinotecanCamptoAventis PharmaLCMS/MS20 mg/ml16.32 ng/ml30.73 ng/ml
11MethotrexateLedertrexateWyeth LederleLCMS/MS25 mg/ml1.41 ng/ml12.85 ng/ml
12ThiotepaLedertepaAstaMedicaLCMS/MS10 mg/ml3.06 ng/ml17.36 ng/ml
13VinorelbineNavelbinePierre FabreLCMS/MS10 mg/ml6.48 ng/ml43.72 ng/ml

Ansell Gloves Cytostatics permeation chart

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* LC-MS/MS: Liquid Chromatography Tandem Mass Spectrometry
** HPLC -DAD: High Pressure Liquid Chromatography - Diode Array Detection
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