Type IV allergy: Mechanism
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| Type IV allergy is an immune reaction, of the delayed hypersensitivity type, mediated by cells, T-cells, and not by antibodies. |
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| Type IV allergy is induced by penetration of natural or synthetic low-molecular weight compounds into the skin ( haptens ). Haptens only become immunological after covalent or non-covalent binding to the proteins of epidermal cells (or carrier cells) and enzymatic digestion in cells presenting with the antigen (Langerhans cells) in the skin. |
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